چکیده:
Purpose: Obesity is considered a growing cause of cardiovascular diseases. The cellular and vascular cell adhesion molecules have been identified as the new inflammatory indicators of forecasting and predicting cardiovascular diseases. The purpose of this study, therefore, was to investigate the effect of selected aerobic activities and consumption of omega-3 supplementation on plasma concentrations of sICAM-1 and sVCAM-1 in elderly obese women.Material and Methods: In a double-blinded study, 40 obese women (BMI ≥ 30) 55 to 65 years old, were selected in a non-random and easily-accessible way and were randomly categorized into 4 groups of 10 individuals: exercise-placebo, exercise-supplements, supplements, and placebo. Subjects in the supplement groups consumed 2080 mg of omega-3 supplement for 8 weeks and placebo groups used sunflower oil produced in Zachariah Company, as placebo. Exercise program included aerobic exercise activities at 45 to 60 percent of maximum heart rate for 8 weeks, three 60-minute sessions per week. After 12 h fasting in the pre- test and 48 h fasting after the last training session, blood sampling was conducted. Data analysis included paired-t test and two-way ANOVA and was carried out using SPSS software (version 16).Results: The obtained results showed that there was a significant interaction between exercise and supplements in reducing serum sICAM-1 factor, suggesting that sICAM- 1 reduction was both influenced by the separate effects of supplements and exercise, and the combined intervention of both exercise and supplements which had a synergistic effect on reducing the concentrations of this inflammatory factor. In addition, serum sVCAM-1 decreased significantly only in the exercise-supplement group (combined) (P < 0.05).Discussion and Conclusion: The results indicated that considering sensitivity and accuracy of new inflammatory indices, measuring these indicators could be useful in the diagnosis of inflammation and vascular disorders. Besides, regular aerobic exercise and omega-3 supplements are two effective and moderating factors reducing the level of adhesion molecules (sICAM-1 and sVCAM-1) and inflammation.
خلاصه ماشینی:
"Besides, regular aerobic exercise and omega-3 supplements are two effective and moderating factors reducing the level of adhesion molecules (sICAM-1 and sVCAM-1) and inflammation.
Becky et al also (2010) conducted a study investigating the effects of a cardiac rehabilitation exercise program on inflammation and metabolic syndrome in 91 patients (with the mean age of 61 years) with cardiovascular diseases and indicated that participating in a 12-week cardiac rehabilitation exercise program was associated with a significant decrease in the plasma serum level of sICAM-1 [6].
In this regard, Hjerkinn et al (2005) in a study on hyperlipdemic individuals showed that daily consumption of 2/4 grams of EPA and DHA fatty acids for three years significantly decreased sICAM-1 concentration in the experimental group compared to the control group while no significant change was observed in serum levels of sVCAM-1 and sE-selectin [14].
Accordingly, and based on previous studies, this study was undertaken to investigate the effects of aerobic exercise and omega-3 supplementation on adhesive molecules in obese patients in order to help preventing cardiovascular diseases and promote public health.
Conclusion In summary, the results of the present study indicated that 8 weeks of aerobic exercise along with omega-3 fatty acids consumption reduced the amount of body fat and inhibited the upstream processes of the production of new cardiovascular risk factors, which consequently reduced serum concentrations of these factors, minimizd the negative effects of inflammation in elderly obese women."